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How do the enzymes used in a chemical bichectomy work?

Day by day, more and better treatments emerge to delay the annoying signs of aging on our face. Such is the case of  chemical bichectomy, a cutting-edge technique that uses enzymes to restore youth to the face. How do they work? Here we tell you

Three enzymes to rejuvenate

There are three recombinant enzymes that can be applied simultaneously to successfully reduce fat in the submental region during a chemical bichectomy:

1. Lipase

This is the most important enzyme we need to remodel the subcutaneous tissue and reduce the double chin. Triglycerides are the specific substrate of this enzyme, so Lipase reduces fat by binding to triglycerides that accumulate inside adipocytes in adipose tissue.  

After binding to the corresponding triglyceride, it will become a molecule of glycerol and three molecules of free fatty acids, which will enter the bloodstream to be captured by the tissues in order to obtain energy.

While human lipase is regulated by hormones such as catecholamines or insulin, and its effect depends on these hormones, recombinant lipase is not sensitive to hormonal regulation, which makes it very effective at any time. It will not be inhibited by the action of insulin, regardless of the amount of insulin and sugar in the blood.

2. Collagenase

The submental fat pad is surrounded by the extracellular matrix where collagen fibers are located above the adipocytes, which can make it difficult for lipase to reach the site of action. 

In cases where excess collagen needs to be dissolved to help reduce fat content, collagenase is used. It is safe to use this enzyme to dissolve collagen because collagen no longer provides a structural scaffold.

The removal of these collagen fibers will also promote the activation and proliferation of fibroblasts, which will synthesize new collagen. These new, stronger collagen fibers will provide a tightening effect, renewing firmness and elasticity in the submental area.

3. Hyaluronidase

Submental fat can be improved by reducing the double chin: an enzymatic approach to fluid retention in the extracellular matrix, making it more noticeable. We can solve this problem thanks to the action of hyaluronidase.  

This enzyme breaks down extracellular polysaccharides, which are responsible for water retention in the extracellular matrix. By breaking down these molecules, hyaluronidase releases trapped fluid that has built up in the tissue.

By reducing fluid retention, this enzyme also facilitates the diffusion of other enzymes through the extracellular matrix, helping them reach their site of action.

Are you worried about the signs of aging on your body? At Benavides Aesthetic Medicine we can help you recover the beauty and harmony of your body and face. We have the treatment you are looking for.  Contact us   to learn more. 


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